Most if not all individuals presenting with Autism show significant oxygen metabolic dysfunction. Typically these indviduals present:

• Multiple indications of liver dysfunction/damage
• High levels of Red Blood Cell dysfunction/damage
• Chronic Immunological / Inflammatory challenge
• Cognitive/behavorial dysfunction likely related to brain hypoxia
• Significant acid/alkali dysregulation
• Chronic Hypotension / Low Blood Pressure

It seems likely that a significant fraction of the durable symptoms of autism result from the capillary switch mechanism documented by Manfred von Ardenne.

Here is a pathology model based on the capillary edema model:

1. In an pre-autistic child;
2. Chemical stress triggers a traumatic decrease in blood oxygen desaturation;
3. Desaturation results in hypoxia in capillaries throughout the body;
4. Which triggers capillary endothelial swelling;
5. In many systems throughtout the body, brain, bone marrow, pancreas, liver, etc.;
6. Swelling creates durable (permanent) flow restriction through affected capillaries;
7. Which permanently inhibits nutrient and oxygen delivery to tissue beds served by the capillaries;
8. Which inhibits repair of core healing systems;
9. Which prevents systemic healing;
10. Which when severe enough reaches a point-of-no-natural-return;
11. Which makes the condition permanent.

Note that we have observed variance in agglutination tendencies in autistic children which suggests that simple agglutination does not explain the why healing is permanently prevented in many autistic cases.

This model proposes that the zeta shock, triggers agglutination, which in turn switches on capillary edema, which is the long term reason why healing fails. The capillary edema mechanism is exhaustively discussed in Oxygen Multistep Therapy, by Manfred von Ardenne (text at this link).

The goal of this protocol section is to suggest an OMST therapy model which targets these issues. For background research, please see the appropriate references:

• Liver (See patents on liver hyperthermia & Oxygen)
• Brain (See references on Local Hyperthermia)
• Immune Support
• Hypotension

OMST vs Hyperbaric

Unlike long duration hyperbaric therapy which can use many dives, this protocol, when optimally used, produces results in one or two applications (for high level), and in 36 hours of cumulative therapy, (for low level). Moreover the equipment for OMST costs less about 15% of hyperbaric systems. The combination of high performance and low cost make it a very appealing therapy choice.

OMST generally increases tissue oxygen availability by about 20x, while HBOT, is in the range of 2-3x. For capillary switch triggering, this observation explains the apparent performance difference between OMST and HBOT.

OMST creates much lower oxidative stress than HBOT, normally about 2%. Many autistics show extremely elevated oxidative stress profiles, and long term oxidative pressure can cause adverse responses.

Autism Protocol

The traditional OMST protocols required raising body temperature to 104 degrees, or agressive exercise while breathing very high levels of oxygen.

Heat vs Exercise. Autistic kids present treatment challenges. The trick is to find a therapy which is at least tolerable and preferably fun. This challenge demands creativity from parents. Generally there are two strategies to achieve the metabolic activation required to trigger capillary switching, using heat or exercise.

Heat is a challenge because body temperatures above about 100 degrees F, are quite uncomfortable.

The discomfort at this heat level is beyond the tolerance for most individuals with autism. This author suggests that "repeated low stress" treatments at home in a comfortable environment are much more achievable for the parent and child.

We are developing an "oxygen play room" concept. The challenges:

• Create an affordable system;
• With an enclosed area small enough to enable an affordable oxygen concentration system to create a therapeutic oxygen concentration;
• But big enough to be tolerable for the child/parent for exercise activity;
• To get pulse > 110 beats per minute;
• For at least 15 minutes;
• To trigger the "capillary switching threshold".

The goals of this protocol are:

• Maintain Protocol duration to kid-tolerable time between 15 and 45 minutes;
• Use tolerable repetition instead of agressive shock to incrementally achieve therapy goals;
• Maintian parent/child tolerance and comfort
• Provide alternative oxygen adminstration alternative to mask (canula & tent)
• Administer supplements in non-pill form when possible.

Recommended Equipment

This equipment is recommended for monitoring and adminstering OMST to autistic kids.

• Oxygen Delivery Device (Tent, child oxygen mask or canula)
• Whole body heat source (Biomat, IR Sauna, or Hot Bath)
• Oxygen Concentrator (5+ liter/minute for mask or canula, 10+ l/min for tent)
• Wrist Blood Pressure Cuff (montor pre/post Blood pressure and therapy effects)
• Infrared Forehead Thermometer (measure core temperature effects during therapy)
• Pulse oxymeter (to measure oxygen saturation & desaturation performance)

Note if your child likes an active exercise activity which fits in a tent, consider the "exercise" a replacement for "hyperthermia". The goal is to increase pulse to 110 beats/minute while breathing near 100% oxygen, while using the supplements. Hyperthermia and exercise are methods to increase metabolic activity.

Supplements

Each supplement activates an aspect of the therapy. The basic supplement group provides basic vasodilator and blood oxygen absorption agents. The supplemental agents are vasodilators which provide immediate elevation in nitric oxide which is serves as a vascular neurotransmitter which opens the vascular system is the active agent in vasodilators.

Low Blood Pressure Modulation (as indicated)

• Niacin 100 mg (Increase blood flow with modest flush). Documented to reverse low blood pressure.

Immune Activation (as indicated)

• 500 mg Thymus Extract

Basic Oxygen Supplement:

• 100 mg Thiamine (Vitamin B1)
• 200 mg Magnesium Orotate
• 3000 mg L-Arginine alphaketoglutrate
• 200 mg Vitamin C

Pharmaceutical Vasodilators (if available)

• Amyl Nitrite (See notes)
• Glyceryl trinitrate (Nitro Glycerine)

Exercise Protocol

1. Take Basic Oxygen Supplement
2. Wait 20-30 minutes
3. Breathe oxygen and
4. Continue hyperthermia or exercise activity to tolerance or 1 hour
5. Take Basic Oxygen Supplement
6. Rest as needed
   

Notes:

• Amyl Nitrite is a potent vasodilator, pharmacology. It is available in non-pharmacological form as a room aroma.

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